… Cardiac screening or genetic testing of younger children … cardiac follow-up in a cohort of
predictively tested children (<18 … children visit our outpatient clinic for a predictive genetic test, …

… penetrance, and is most often caused by variants in genes … be included in clinical follow-up
programs with possibilities … and sensitivity of predictive genetic testing in HCM. Future …

… Mann–Whitney test was used for length of follow-up with all … predictive genetic testing may
be a more cost-effective way to … study is likely to be an underestimate of the true penetrance …

… cardiology reference center and assessed the predictive value of genetic testing. We also
analyzed the age-related penetrance of the disease during the follow-up of these young …

… a single family in Northern Tasmania in whom predictive gene testing was conducted [2], [20].
This … Family 2 is known to have a genetic mutation of relatively high penetrance, with the …

… to be a significant predictor of HCM penetrance in this cohort … A follow up study from the
United Kingdom was conducted to … was 6% over the course of the 12-year follow-up. Of note, the …

… Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up
study of clinical screening and predictive genetic testing. Circulation. 2013;127:48-54. …

… and short duration of follow-up were important limiting factors, … only predictor of the presence
and extent of LGE in our study. … penetrance but, to the best of our knowledge, this is the first …

… from clinical follow-up in 46% of the study population. … where cardiac evaluation and genetic
counseling and testing are … the described age-related penetrance of HCM. A younger age at …

… Genetic testing identifies a P/LP variant in ≈30% to 40… studies including older carriers
reported higher penetrance rates. This emphasizes the need for studies with extended follow-up of …